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    Celexa (citalopram) and Lexapro (escitalopram) are chemically-analogous medications within the selective-serotonin reuptake inhibitor (SSRI) classification that are regularly prescribed for the management of neuropsychiatric disorders. General [obvious] differences between Celexa and Lexapro include: release dates; authorized (FDA) medical uses (U. Other suspected differences between Celexa and Lexapro might include: elimination half-life; therapeutic efficacy; incidence of specific side effects; and/or tolerability. Though Celexa and Lexapro are manufactured in the same number of dosing increments (3 for tablet; 1 for oral solution), Celexa dosages are double (in milligrams) the corresponding dosages of Lexapro. Chemically, Celexa contains enantiomers S-citalopram and R-citalopram – whereas Lexapro solely contains S-citalopram (hence its chemical name “es-citalopram”). As was mentioned, citalopram (Celexa) was first synthesized in 1972 and approved for medical use in 1998 within the U. – whereas escitalopram (Lexapro) was synthesized in 1997 and approved for medical use in 2002 within the U. The reason Celexa dosages (in milligrams) are 2-fold the corresponding dosages of Lexapro is because Celexa contains a racemic blend of 50% S-citalopram and 50% R-citalopram – whereas Lexapro contains 100% S-citalopram. The chemical “citalopram” (Celexa) was originally synthesized in 1972 by scientists at the pharmaceutical company Lundbeck whereafter it was released in 1989 for medical use in Denmark. It is thought that the S-citalopram isomer modulates neurochemistry in ways that yield therapeutically-relevant effects – and that R-citalopram isomer fails to modulate neurochemistry therapeutically-relevant ways. Celexa eventually received FDA approval in 1998 for the treatment of major depressive disorder in the United States. Since Celexa is diluted with an equal mixture of S-citalopram and R-citalopram, and Lexapro is concentrated with the therapeutically-relevant S-citalopram – the dosage increments of Celexa end up double (in milligrams) the corresponding dosage increments of Lexapro. Development of “escitalopram” (Lexapro) began in 1997 as a collaboration between pharmaceutical companies Lundbeck (developer of Celexa) and Forest Laboratories. Moreover, while the principal mechanism of action for Celexa and Lexapro is identical, the medications exhibit subtle differences in pharmacodynamics. Lexapro received FDA approval for the treatment of major depressive disorder (MDD) in 2002 and generalized anxiety disorder in 2003 – within the United States. Celexa exhibits less selectivity than Lexapro in that Celexa interacts with: H1 histamine receptors, 5-HT2C receptors; alpha-1 adrenergic receptors; M1 muscarinic receptors; and the NET (norepinephrine transporter). Below is a chart in which general attributes of Celexa (citalopram) and Lexapro (escitalopram) are documented. Lexapro exhibits the most selective action of all serotonergic antidepressants in that it does not significantly interact with many neurochemical targets beyond the serotonin transporter (SERT). Difference between citalopram and sertraline - Answers on. prednisone eye side effects Compare Citalopram vs Sertraline - Treato Citalopram and Escitalopram A Summary of Key Differences and.
     
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