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To compare the analgesic efficacy of tramadol-ketoprofen over a control group in three management schemes in infusional therapy; to control the painful entity (shoulder pain post-laparoscopy surgery). Clinical trial non-randomized; Group I (n = 15) managed with ketorolac 1mg/kg; Group II (n = 12) ketoprofen 100mg; Group III (n = 14) ketoprofen 50 mg plus tramadol 50 mg and Group IV (n = 15) ketoprofen 100 mg plus tramadol 100 mg. The variability analyzed was: Pain, pain bailouts, side effects and patient satisfaction. The highest intensity of pain was found in Group I (conventional) , unlike Group II and III where the predominant category was mild pain, the Group IV presents minimal pain events; 98% significance of p Introduction: Post-operative pain with difficult control, is a reality that can occur in patients undergoing laparoscopic cholecystectomy, it is good comprehensively assess the patient and give a painkiller scheme that ensures the absence of pain. 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