Lexapro (escitalopram) and Zoloft (sertraline) are medications of the selective-serotonin reuptake inhibitor (SSRI) classification utilized most commonly for the management of major depressive disorder (MDD). Zoloft was developed by the pharmaceutical company Pfizer Inc. By scanning the chart, it should be easy to pinpoint the obvious similarities and differences between these medications. Interacts with the serotonin transporter (SERT) to prevent reabsorption of serotonin into the presynaptic neuron. Lexapro was co-developed by the pharmaceutical companies Lundbeck and Forest Laboratories (starting in 1997) and received U. Additional (less significant) actions: -Dopamine reuptake inhibitor -Increases extracellular norepinephrine -Sigma-1 receptor antagonist: This chart may be subject to inaccuracies and/or outdated information. Included below is a chart highlighting general attributes of Lexapro (escitalopram) and Zoloft (sertraline). Both Lexapro and Zoloft function by modulating concentrations of serotonin (5-HT) within the brain to generate antidepressant and anxiolytic effects. If you ever have any specific questions about the attributes of Lexapro and/or Zoloft – it is recommended to contact a medical doctor or pharmacist. Noteworthy differences between Lexapro and Zoloft include: official medical uses; off-label uses; bioavailability, metabolism specifics; elimination half-life; date of release; and incidence of specific side effects. Though both Lexapro and Zoloft are officially approved to treat major depressive disorder (MDD), only Lexapro is medically indicated for the treatment of generalized anxiety disorder (GAD). FDA) to treat a greater number of medical conditions than Lexapro. how to buy cytotec in dubai Have you taken the SSRI antidepressant Zoloft (Sertraline) to help with your depression? Millions of people have taken this antidepressant and many have had success with managing depressive symptoms. However, since the drug doesn’t work for everyone and/or individuals may not want to be on an antidepressant for life, they eventually decide to come off of the drug. Withdrawal from an SSRI (selective-serotonin reuptake inhibitor) can be much more difficult than most psychiatrists think. If you do not know what symptoms to expect, they may catch you off guard and your entire reality may get shook up. For many people, SSRI withdrawal is among the most difficult emotional experiences they will ever have to go through in their lives. For me personally, my withdrawal from Paxil was arguably the toughest thing I’ve ever experienced. Cheap cialis in the us Will doxycycline treat syphilis Buy vegetal vigra Sertraline 50mg tablets. Each film-coated tablet contains 50 mg sertraline. The co-administration of sertraline 200 mg daily did not potentiate the effects. cialis with food or empty stomach Sertraline Aurobindo 50 mg filmomhulde tabletten Witte, capsulevormige, filmomhulde tabletten waarbij aan de ene kant een 'A' is gegraveerd en waarbij aan. Results of the study suggested that sertraline 50 to 150 mg/day. If either Lexapro or Zoloft is administered regularly i.e. daily for weeks. Sertraline is indicated for the treatment of: Major depressive episodes. Prevention of recurrence of major depressive episodes. Obsessive compulsive disorder (OCD) in adults and paediatric patients aged 6-17 years. Post traumatic stress disorder (PTSD) Depression and OCD Sertraline treatment should be started at a dose of 50 mg/day. Panic Disorder, PTSD, and Social Anxiety Disorder Therapy should be initiated at 25 mg/day. After one week, the dose should be increased to 50 mg once daily. This dosage regimen has been shown to reduce the frequency of early treatment emergent side effects characteristic of panic disorder. Depression, OCD, Panic Disorder, Social Anxiety Disorder and PTSD Patients not responding to a 50 mg dose may benefit from dose increases. Dose changes should be made in steps of 50 mg at intervals of at least one week, up to a maximum of 200 mg/day. Initial: 50 mg q Day PO given continuously throughout menstrual cycle or given during luteal phase only May increase by 50 mg at the onset of each new menstrual cycle; no more than 150 mg q Day when administered continuously or 100 mg q Day when administered during luteal phase only 25 mg PO q Day initially; may increase by 25 mg every 2-3 days; not to exceed 200 mg q Day Alzheimer dementia related depression: Start at 12.5 mg/day and titrate every 1-2 weeks to response; not to exceed 150-200 mg Renal impairment: Dose adjustment not necessary Mild hepatic impairment (Child-Pugh 5-6): Decrease recommended starting dose and therapeutic dose by 50% Moderate-to-severe hepatic impairment (Child-Pugh 7-15): Not recommended; sertraline is extensively metabolized, and the effects in patients with moderate and severe hepatic impairment have not been studied Clinical worsening and suicide ideation may occur despite medication Use caution in patients with seizure disorders May worsen mania symptoms or precipitate mania in patients with bipolar disorder Increases risk of hyponatremia and impairment of cognitive/motor functions in the elderly Increases risk of bleeding in patients taking anticoagulants/antiplatelets concomitantly Risk of mydriasis; may trigger angle closure attack in patients with angle closure glaucoma with anatomically narrow angles without a patent iridectomy Pregnancy: Conflicting evidence regarding use of SSRIs during pregnancy and increased risk of persistent pulmonary hypertension of the newborn (see Pregnancy) In neonates exposed to SNRIs/SSRIs late in third trimester: Risk of complications such as feeding difficulties, irritability, and respiratory problems Avoid abrupt withdrawal Bone fractures reported with antidepressant therapy; consider the possibility if patient presents with bone pain, bruising, or point of tenderness Coadministration with other drugs that enhance the effects of serotonergic neurotransmission (eg, tryptophan, fenfluramine, fentanyl, 5-HT agonists, St. John’s Wort) should be undertaken with caution and avoided whenever possible due to the potential for pharmacodynamic interaction (see Contraindications) May cause false-positive urine immunoassay screening tests for benzodiazepines SSRIs and SNRIs are associated with development of SIADH; hyponatremia reported Several SSRIs (eg, fluoxetine, fluvoxamine, paroxetine, sertraline) are metabolized by CYP2D6 CYP2D6 is involved in the metabolism of approximately 20% of drugs in clinical use and displays large individual-to-individual variability in activity due to genetic polymorphisms More than 80 CYP2D6 variant alleles have been identified; however, 4 of the most prevalent alleles, CYP2D6*3, *4, *5, and *6, account for 93-97% of CYP2D6 poor metabolizers CYP2D6*4, the most common variant (~25% frequency in whites), causes a splicing defect; CYP2D6*3 (2.7% frequency) causes a frameshift mutation; and CYP3D6*5 (2.6%) is an entire deletion of the CYP2D6 gene; individuals homozygous for these alleles have no CYP2D6 activity The impact of CYP2D6 activity is further complicated in some SSRIs (eg, fluoxetine, fluvoxamine, paroxetine, sertraline) because in addition to being substrates for CYP2D6, they are also known to moderately inhibit CYP2D6 activity The above information is provided for general informational and educational purposes only. 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