Inflammation caused by lupus can affect many different body systems — including your joints, skin, kidneys, blood cells, brain, heart and lungs. Lupus can be difficult to diagnose because its signs and symptoms often mimic those of other ailments. Aralen uses Plaquenil and laser eye surgery Sep 30, 2016 Systemic lupus erythematosus SLE is a chronic multisystem autoimmune disorder in which 20 % of patients are diagnosed in childhood. Childhood-onset SLE is associated with higher morbidity and mortality than adult-onset SLE. The aims of disease management with early immunosuppression are to decrease disease activity and improve quality of life. It also is known that some women with systemic lupus erythematosus can experience worsening of their symptoms prior to their menstrual periods. This phenomenon, together with the female predominance of systemic lupus erythematosus, suggests that female hormones play an important role in the expression of SLE. INTRODUCTION Hydroxychloroquine HCQ is an alkalinizing lysosomatropic drug that accumulates in lysosomes where it inhibits some important functions by increasing the pH. HCQ has proved to be effective in a number of autoimmune diseases including systemic lupus erythematosus SLE. Some people are born with a tendency toward developing lupus, which may be triggered by infections, certain drugs or even sunlight. The most distinctive sign of lupus — a facial rash that resembles the wings of a butterfly unfolding across both cheeks — occurs in many but not all cases of lupus. Plaquenil and systemic lupus Side Effects of Plaquenil Hydroxychloroquine, Warnings, Uses, Systemic Lupus Erythematosus SLE or Lupus - MedicineNet Hydroxychloroquine and apsHydroxychloroquine and alcohol usePlaquenil medicine side effectsChloroquine retinopathy oct Hydroxychloroquine Plaquenil, chloroquine Aralen, and quinacrine Atabrine are medications that were originally used to prevent or treat malaria. However, during World War II it was also found that these medications were effective in treating the symptoms of lupus. Treating Lupus with Anti-Malarial Drugs Johns Hopkins.. Hydroxychloroquine in systemic lupus erythematosus SLE.. Lupus - Symptoms and causes - Mayo Clinic. Lupus and Plaquenil research While Plaquenil was not created with the explicit purpose of helping people minimize the disease activity of lupus, a number of clinical trials have been conducted to examine the clinical impact of the medication. Anti-malarial drugs, such as Plaquenil hydroxychloroquine, is often used to manage lupus and can also be effective in scleroderma. Plaquenil is thought to interfere with communication between immune cells, which can suppress the damaging effect of an overly active immune response without raising a patient’s risk of susceptibility to infections. User Reviews for Plaquenil to treat Systemic Lupus Erythematosus The following information is NOT intended to endorse any particular medication. While these reviews might be helpful, they are not a substitute for the expertise, skill, knowledge and judgement of healthcare practitioners.