The main finding in scleroderma is thickening and tightening of the skin and inflammation and scarring of many body parts, leading to problems in the lungs, kidneys, heart, intestinal system and other areas. Twins and family members of those with scleroderma or other autoimmune connective tissue diseases, such as lupus, may have a slightly higher risk of getting scleroderma. There is still no cure for scleroderma, but effective treatments for some forms of the disease are available. Children can also develop scleroderma, but the disease is different in children than in adults. Hydroxychloroquine sulphate tablets uses Chloroquine together with proguanil For example, the CREST syndrome Calcinosis, Raynaud’s phenomenon, Esophageal dysmotility, Sclerodactyly, Telangeictasias falls into the traditional limited subtype; yet evidence suggests that survival is better in those with the CREST syndrome than an intermediate group of patients in the limited group who have skin changes extending onto. Plaquenil Hydroxychloroquine at this stage will not help her scleroderma much, especially the esophagus, which is already dilated with no motility. This is one of the few conditions of scleroderma. Hydroxychloroquine Plaquenil is considered a disease-modifying anti-rheumatic drug DMARD. It can decrease the pain and swelling of arthritis. It may prevent joint damage and reduce the risk of long-term disability. A great deal of research is also underway to find better treatments for scleroderma and, hopefully, someday a cure. Although the underlying cause is unknown, promising research is shedding light on the relationship between the immune system and scleroderma. Hydroxychloroquine for crest syndrome Plaquenil pros and cons - Sclero Forums MAIN - Sclero Forums, Common "Crest Syndrome" queries answered by top doctors iCliniq Fda warning letter sandoz hydroxychloroquinePlaquenil photosensitivity rash cheeks What is CREST syndrome? CREST Syndrome is a form of scleroderma that is characterized by least two of the following symptoms calcinosis, Raynaud's phenomenon, esophageal dysfunction, sclerodactyly, telangiectasia. Common symptoms reported by people with CREST syndrome CREST syndrome symptoms, treatments & forums PatientsLikeMe. Hydroxychloroquine Plaquenil -. Prognosis and treatment of mixed connective tissue disease.. Long term ratings 3/5. This is a reivew of how effective Plaquenil hydroxychloroquine sulfate is for Systemic sclerosis scleroderma and for what kind of people. The study is created by eHealthMe from 11 Plaquenil users and is updated continuously. eHealthMe has been monitoring drugs and supplements since 2008. I stopped Plaquenil eons ago prior to Cytokine testing and haven't needed to get back on it. While it is a good drug, it is a good drug for what it's indicated for and CREST syndrome, lupus, Sjogrens and other auto-immune conditions will benefit from it. As a reminder it will only work if taken over the long term. In Limited cutaneous systemic sclerosis CREST syndrome, skin thickening and tightness is typically limited to the fingers and toes. This form of scleroderma is also associated with the formation of calcified nodules under the skin, Raynaud’s phenomenon, problems with movement of the esophagus, and dilated blood vessels in the skin called.