This medicine is also sometimes given off-label to help the following conditions: Also, let your doctor know if you drink large amounts of alcohol before starting on this medicine. Your doctor will probably want to order frequent tests to check your body's response to chloroquine. Why would you take hydroxychloroquine and mycophenolate Hydroxychloroquine for lichen planus What is hydroxychloroquine and sob Chloroquine-sensitive uncomplicated malaria Plasmodium species or species not identified 600 mg base 1 g salt orally at once, followed by 300 mg base 500 mg salt orally at 6, 24, and 48 hours Total dose 1.5 g base 2.5 g salt CAS# 54-05-7 free base Description Chloroquine is a medication used to prevent and to treat malaria in areas where malaria is known to be sensitive to its effects. Certain types of malaria, resistant strains, and complicated cases typically require different or additional medication. Chloroquine also known as chloroquine phosphate is an antimalarial medicine. It is available in the. United States by prescription only. It is sold under the brand name Aralen, and it is also sold as a generic medicine. It is available in tablets of two sizes 150mg base 250mg salt and 300mg base 500mg salt. Let your healthcare provider know if your symptoms either don't improve or worsen while taking this medicine. Keep all appointments with your doctor and laboratory. Chloroquine free base Chloroquine - FDA prescribing information, side effects., Chloroquine free base CAS#54-05-7 antimalarial agent MedKoo How does plaquenil work on the immune systemChloroquine hydrochloride propertiesHydroxy chloroquine resistant malariaIntravenous chloroquine injection Chloroquine enters the red blood cell by simple diffusion, inhibiting the parasite cell and digestive vacuole. Chloroquine then becomes protonated to CQ2+, as the digestive vacuole is known to be acidic pH 4.7; chloroquine then cannot leave by diffusion. Chloroquine - Wikipedia. Medicines for the Prevention of Malaria While Traveling.. Chloroquine - Chemie. Chloroquine is the drug of choice in the few malaria-endemic areas free of CRPf. Combining chloroquine and proguanil is an option for CRPf when other first-line antimalarials are contraindicated. Dosage should be calculated in terms of the base. The adult chloroquine dose is 300 mg base weekly or in some countries 100 mg base daily. In most cases, 250 mg tablets have an equivalence of 150 mg chloroquine base, and 500 mg tablets have an equivalence of 300 mg chloroquine base. Although the purity mentioned above is generally accurate, it would be best to verify the chloroquine base contained in the tablets of your choice in order to be able to properly calculate the exact dosage. The mode of action of chloroquine is as a weak lipophilic base where the free base passes easily through membranes 34. It accumulates in the acidic lysosome as it becomes protonated, increasing the pH of the lysosome 35, 36. Following exposure to concanamycin A, BMPR-II accumulates in the lysosome.