Although not all of these side effects may occur, if they do occur they may need medical attention. Check with your doctor immediately if any of the following side effects occur while taking hydroxychloroquine: Incidence not known Some side effects of hydroxychloroquine may occur that usually do not need medical attention. G6pd and hydroxychloroquine Plaquenil steady state Remove chloroquine phosphate Chloroquine-resistant plasmodium falciparum Plaquenil is a prescription medication used to reduce pain and swelling caused by diseases of the immune system such as rheumatoid arthritis, juvenile arthritis, and systemic lupus erythematosus SLE. This medication belongs to a group of drugs called DMARDs disease modifying antirheumatic drugs which work by suppressing the excessive activity of the immune system. Plaquenil Dosage Malaria. Adults 400 mg 310 mg base once weekly on the same day of each week starting 2 weeks prior. Lupus Erythematosus. The recommended adult dosage is 200 to 400 mg 155 to 310 mg base daily. Rheumatoid Arthritis. The action of hydroxychloroquine is cumulative and may. PLAQUENIL hydroxychloroquine sulfate tablets is indicated for the treatment of rheumatoid arthritis, and discoid and systemic lupus erythematosus, in patients who have not responded satisfactorily to drugs with less potential for serious side effects. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. These side effects may go away during treatment as your body adjusts to the medicine. Information on the medication plaquenil French Study Finds Anti-Malaria Drug Chloroquine May Be., Plaquenil Dosage Guide - How much weight loss on plaquenilTaking melatonin with hydroxychloroquineDoes plaquenil cause hair to.lightenChloroquine phosphate in pregnancy Hydroxychloroquine is also an antirheumatic medicine and is used to treat symptoms of rheumatoid arthritis and discoid or systemic lupus erythematosus. Important information. Taking hydroxychloroquine long-term or at high doses may cause irreversible damage to the retina of your eye. Hydroxychloroquine Uses, Dosage & Side Effects -. Plaquenil Hydroxychloroquine Sulfate. Plaquenil Hydroxychloroquine - Side Effects, Dosage.. The dosage and length of treatment are based on your medical condition and response to therapy. In children, dosage is also based on weight. For malaria prevention, take this medication by mouth once a week on the same day of the week, or as directed by your doctor. To make sure Plaquenil is safe for you, tell your doctor if you have a history of vision changes or damage to your retina caused by an anti-malaria medication; heart disease, heart rhythm disorder such as long QT syndrome; diabetes; a stomach disorder; an allergy to quinine; liver or kidney. Renal clearance in rheumatoid arthritis RA patients taking Plaquenil for at least six months seemed to be similar to that of the single dose studies in volunteers, suggesting that no change occurs with chronic dosing. Range for renal clearance of unchanged drug was approximately 16 to 30%.