I am very underweight and do have chronic diarrhea, but gosh, this seems invasive as a first step in trying to figure out . Has anyone had chronic diarrhea/weight loss from Plaquenil? Autofluorescence imaging in plaquenil Hydroxychloroquine for early rheumatoid arthritis reviews Can you take 800mg of plaquenil Depending on what you're being treated for, it can take up to 6 months for the full benefits of Plaquenil hydroxychloroquine. Many people have nausea, stomach cramps, and diarrhea when they first start taking Plaquenil hydroxychloroquine. What are the side effects of Plaquenil? The most common side effects are diarrhea, nausea, vomiting, headache, dizziness, skin rash or black spots when you look at things. Most side effects will go away when your body gets used to the medicine. Rarely it can cause an upset stomach or diarrhea. Skin rash – Plaquenil can rarely cause a rash. Patients who experience this rare side effect should stop taking this medicine and contact their doctor. Headaches – Plaquenil can rarely cause a headache. Sun Sensitivity – Plaquenil can sometimes make the skin more sensitive to the sun. My rheumatologist nor the GI doctor have suggested alternate treatments to see if it could be the problem. I know it can be a temporary side effect for some, but I've been on it for a year. Plaquenil nausea diarrhea Hydroxychloroquine Side Effects Common, Severe, Long Term., Lupus Medicines Hydroxychloroquine - Brigham and Women's. Hydroxychloroquine wikikRegimens of chloroquineCan plaquenil cause kidney problemsPlaquenil and itchy eyes Nausea from Plaquenil, etc. nowah1965 posted. Plaq did give me diarrhea, and there are OTC meds like Immodium AD and script meds like Hyoscyamine that can help there. Over time my tummy adjusted to Plaq. I did find that taking it with milk made my tummy troubles worse, but it is recommended to take it with food. Nausea from Plaquenil, etc" Lupus Community - Support Group. Plaquenil – RheumInfo. Hydroxychloroquine Plaquenil. I’ve been on plaquenil for almost 3 years and I still have diarrhea and to a lesser extent heartburn and nausea sometimes. The first year or two I was on plaquenil I didn’t have a normal bowel movement for as long as I could remember and was constantly nauseous and could barely eat. I've been taking Plaquenil for one month 1 x 200 mg. I should have taken 2 x 200 mg but from the beginning I had diarrhea and stomach pain. If I want to increase the Plaquenil my complaints get worse. My Dr. prescribed Plaquenil the other day, I took 2-200mg pills in a 24 hr period and I was sick as a dog. I had stomach cramps, nausea and painful diarrhea, not to mention heart palpitations and an all over uneasiness. By the end of the 24 hrs I had also contracted a chest cold. Needless to say it was a rough couple of days.