If you take prescription medication, ask your doctor or pharmacist whether your medication interacts with grapefruit or other citrus products. You may need to eliminate grapefruit products from your diet. Plaquenil methotrexate shigles vaccine Chloroquine diphosphate structure Plaquenil uses for lupus Citrus fruits and products, such as lemons, oranges and orange juice. If your heartburn is severe or not relieved with medication, you may need an endoscopy. WebMD Medical Reference Reviewed by. Yes. Grapefruit and certain other citrus fruits, such as Seville oranges, can interfere with several kinds of prescription medications. Don't take these interactions lightly. Some can cause potentially dangerous health problems. Hydroxychloroquine is used to treat discoid lupus erythematosus DLE or systemic lupus erythematosus SLE or lupus. It is also used to treat acute and chronic rheumatoid arthritis. This medicine is available only with your doctor's prescription. Before using Plaquenil Alternatively, you can ask your doctor if there's a comparable medication you can take that doesn't interact with grapefruit. Simply taking your medication and grapefruit product at different times doesn't stop the interaction. Hydroxychloroquine and citrus Plaquenil & other drug interactions ? Lupus Forums at The., Grapefruit Beware of dangerous medication interactions. Can i take phosphatidylserine while taking plaquenilTaking plaquenil twice a dayIs chloroquine safe during pregnancy Safety and efficacy of hydroxychloroquine to treat lupus and arthritis have not been established in children. Geriatric. Appropriate studies performed to date have not demonstrated geriatric-specific problems that would limit the usefulness of hydroxychloroquine in the elderly. Hydroxychloroquine Oral Route Before Using - Mayo Clinic. Plaquenil Advanced Patient Information -. Plaquenil Oral Uses, Side Effects, Interactions.. Hydroxychloroquine Plaquenil is a drug that is classified as an anti-malarial drug. Plaquenil is prescribed for the treatment or prevention of malaria. It is also prescribed for the treatment of rheumatoid arthritis, lupus, and the side effects of lupus such as hair loss, joint pain, and more. WebMD provides information about which foods to avoid while taking Plaquenil Oral. Mar 17, 2017 Grapefruit is a delicious citrus fruit with many health benefits. However, it can interact with some common medications, altering their effects on your body. If you're curious about the grapefruit.