Chloroquine phosphate, which has been used for more than 70 years and is on the World Health Organization’s List of Essential Medicines, the safest and most effective medicines needed in a health system. Chloroquine was discovered in 1934 by Hans Andersag but was initially ignored for a decade because it was considered too toxic for human use. Chloroquine and doxycycline Chloroquine family How often to take aralen Hydroxychloroquine causing neuropathy Rheumatoid Arthritis. PLAQUENIL is indicated for the treatment of acute and chronic rheumatoid arthritis in adults. CONTRAINDICATIONS. Use of PLAQUENIL is contraindicated in patients with known hypersensitivity to 4 aminoquinoline compounds. WARNINGS. Resistant strains of malaria PLAQUENIL is not effective against chloroquine-resistant. Hydroxychloroquine has also been used as an antimalarial, but in addition is now broadly used in autoimmune diseases such as lupus and rheumatoid arthritis. Of note, chloroquine and hydroxychloroquine are considered to be safe and side-effects are generally mild and transitory. Contraindications Hypersensitivity to hydroxychloroquine, chloroquine, or 4-aminoquinolines Precautions Use caution in hepatic disease, psoriasis, and porphyria. Reports suggest that antimalarials may exacerbate psoriasis, but they were often safely used to treat psoriatic arthritis. Aside from preventing and treating malaria, chloroquine is also occasionally used for amebiasis that is occurring outside the intestines, rheumatoid arthritis, and lupus erythematosus. During World War II, United States government-sponsored clinical trials for antimalarial drug development showed unequivocally that chloroquine has a significant therapeutic value as an antimalarial drug. Chloroquine phosphate rheumatoid arthritis Chloroquine MedlinePlus Drug Information, Of chloroquine and COVID-19 - ScienceDirect Plaquenil sarcoidosis treatmentIs plaquenil an immunosuppressantChloroquine lupus treatment Proposed diagnostic criteria for rheumatoid arthritis. Ann Rheum Dis. 1957 Mar; 16 1118–125. PMC free article Google Scholar SCHERBEL AL, SCHUCHTER SL, HARRISON JW. Comparison of effects of two antimalarial agents, hydroxychloroquine sulfate and chloroquine phosphate, in patients with rheumatoid arthitis. Chloroquine in Rheumatoid Arthritis - Europe PMC Article.. Hydroxychloroquine and Chloroquine Phosphate - RheumaKnowledgy. Chloroquine Aralen - Side Effects, Dosage, Interactions - Drugs. Chloroquine Phosphate. Chloroquine is used to prevent or treat malaria caused by mosquito bites in countries where malaria is common. Malaria parasites can enter the body through these mosquito bites, and then live in body tissues such as red blood cells or the liver. Plaquenil hydroxychloroquine has been shown to improve physical function in up to 80% of patients with rheumatoid arthritis. Plaquenil hydroxychloroquine is commonly used for lupus in children because of less side effects compared to other medications. Plaquenil hydroxychloroquine helps minimize joint damage. The 4-aminoquinoline derivatives, including chloroquine, also have anti-inflammatory activity; however, the mechanisms of action of the drugs in the treatment of rheumatoid arthritis and lupus erythematosus has not been determined. Chloroquine reportedly antagonizes histamine in vitro, has antiserotonin effects.