Tell your doctor and pharmacist about all of your drugs (prescription or OTC, natural products, vitamins) and health problems. You must check to make sure that it is safe for you to take chloroquine with all of your drugs and health problems. Hydroxychloroquine substitutions Plaquenil bull's eye retinopathy Chloroquine is a 4-aminoquinoline with antimalarial, anti-inflammatory, and potential chemosensitization and radiosensitization activities. Although the mechanism is not well understood, chloroquine is shown to inhibit the parasitic enzyme heme polymerase that converts the toxic heme into non-toxic hemazoin, thereby resulting in the accumulation of toxic heme within the parasite. Use of chloroquine is declining recently due to the fact that most strains have become resistant. The mortality rate has increased along with the spread of malaria. If after administration, afebrile stage is not achieved within 24-48 hours, it indicates specie is resistant and another drug should be used. A severe eye problem has happened with chloroquine. This may lead to lasting eyesight problems. The risk may be higher if you have some types of eye or kidney problems. The risk may also be higher with some doses of chloroquine, if you use chloroquine for longer than 5 years, or if you take certain other drugs like tamoxifen. Call your doctor. For all uses of chloroquine: WARNING/CAUTION: Even though it may be rare, some people may have very bad and sometimes deadly side effects when taking a drug. Do not start, stop, or change the dose of any drug without checking with your doctor. Chloroquine resistance mechanism DRUG RESISTANT MALARIA CURRENT STATUS, Chloroquine – howMed Plaquenil side effects mood changesHydroxychloroquine and neuropathyPlaquenil help with fatiguePlaquenil withdrawal side effectsTeva chloroquine and alcohol Its mechanism of action is unknown; however, malarial parasites invade human red blood cells, and chloroquine may prevent malarial parasites from breaking down metabolizing hemoglobin in human red blood cells. Aralen chloroquine Malaria Drug Side Effects & Dosage. Chloroquine Indications, Side Effects, Warnings -. Chloroquine Mechanism of action and resistance in malaria.. The clinical usefulness of chloroquine, and in some recent cases of quinine as well, has been much reduced by the evolution and spread of chloroquine resistant malaria parasites. The mechanism of resistance involves a reduced accumulation of the drug, although again the mechanism involved is controversial. Mechanism of Action. Chloroquine is an antimalarial agent. While the drug can inhibit certain enzymes, its effect is believed to result, at least in part, from its interaction with DNA. However, the mechanism of plasmodicidal action of chloroquine is not completely certain. Activity in vitro and in vivo Aug 24, 2017 There has been long-standing interest in targeting pro-survival autophagy as a combinational cancer therapeutic strategy. Clinical trials are in progress testing chloroquine CQ or its derivatives in combination with chemo- or radiotherapy for solid and haematological cancers.