This stands for Disease-Modifying Anti-Rheumatic Drugs. Wait until the next scheduled time, and take your usual dose. Plaquenil tries to quiet or slow down the immune system. If you miss a dose of Plaquenil, do not make it up or double your next dose. Antidote of chloroquine Plaquenil swollen face Plaquenil takes quite a long time to get to its peak effectiveness depending on what you read, anywhere from 3 months to a year. Unless you are having significant side effects, try to give it at least 6 months before you decide it doesn't work for you. Unbearable rash and hives. I look like I have the worst sunburn ever. Every crease in my body like behind knees and elbows hurt like a sunburn. My skin is peeling with scabs. I started having a rash and hives on my upper body about a week after starting Plaquenil but I thought it had to do also with a prednisone pack I had been on. Mar 25, 2015 Although the plaquenil is a good drug, it has a very long half life 6 weeks. It will take a long time to leave the body. If you are allergic and I cannot say whether you are or not, only your Rheumy can then there is an alternative called Quinacrine US or mepacrine UK. Plaquenil changes the way your immune system works. Plaquenil relieves pain and swelling and prevents damage to joints. In some kinds of lupus, your immune system attacks your body instead of protecting it. Your body weight will tell your doctor what dose is safe for you. How long does plaquenil take to work for hives Lupus Medicines Hydroxychloroquine - Brigham and Women's., PLAQUENIL Side Effects, Reviews by Patients - How does hydroxychloroquine treat lupusHydroxychloroquine retinal toxicity screeningHydroxychloroquine and amoxicillinHow does plaquenil affect lichen planus Re Plaquenil - Can It Work Quickly? I tried to get on Plaquenil years ago, and couldn't tolerate it, but now I'm thinking there might be a lessor dose I should try. I'm new to the area, so don't have a rheumy yet. Immune & Autoimmune - Lupus Plaquenil - Can It Work Quickly?. Allergic reaction to Plaquenil Lupus Forums at The Lupus Site. How long does it take for plaquenil hydroxychloroquine to.. Plaquenil is a slow-acting drug, meaning that it can take up to 6 months to experience the full benefits of this medication, but it is possible for symptoms to improve in as few as 1 or 2 months. Plaquenil and other antimalarials are the key to controlling lupus long-term, and some lupus patients may be on Plaquenil for the rest of their lives. How long does it take for plaquenil to work? I just started about 6 weeks ago, the rheum said it can take up to a year. I just started about 6 weeks ago, the rheum said it can take up to a year. Let me know how you are doing on it! Plaquenil is the brand name for the prescription drug hydroxychloroquine. It's used to treat and prevent malaria infection, and to reduce symptoms and progression of autoimmune diseases such as.