Tamoxifen after bilateral mastectomy

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  1. Seva Manager Well-Known Member

    Tamoxifen after bilateral mastectomy


    Breast cancer is the most common type of cancer in women around the world, and the second leading cause of cancer deaths among U. For women whose breast cancer is diagnosed before it has spread, the 5-year survival rate is 99%. The survival rate for early-stage breast cancer is very high. For women whose breast cancer has spread to the lymph nodes, the 5-year survival rate is 85%. Women who are diagnosed with early-stage breast cancer almost always undergo surgery to remove the cancer (either lumpectomy/partial mastectomy or mastectomy). Most will also choose at least one other treatment in addition to surgery: 1) If they have a lumpectomy, they often undergo radiation either to shrink the tumor before surgery or to kill any cancer cells in the breast that were missed during surgery. 2) If their cancer is estrogen receptor positive (about 84% of breast cancers), many women will try to take hormonal therapy for at least five years after surgery to lower the chance of cancer in either breast in the future. For pre-menopausal women, the standard treatment is tamoxifen.[1] Hormonal therapy (also called endocrine therapy or anti-estrogen therapy) is the opposite of the type of hormones women sometimes take to reduce the symptoms of menopause. When a famous person is affected by illness, especially one as serious as cancer, they may publicly share their experiences and when they do, the world takes note. When First Lady Betty Ford went public with the her battle with breast cancer that included a mastectomy (removal of the whole breast) in the 1970s, the “C word” came out of the closet, igniting a revolution in patient advocacy. Ford’s courage led to women taking charge and demanding less disfiguring surgery, breast preservation when possible and attention to their physical and emotional needs. Many years of research and the brave participation of thousands of women in clinical trials proved that for local control of cancer in the breast, the less-invasive “lumpectomy” (removal of only the cancerous tumor) followed by radiation to the breast was equal in efficacy to mastectomy. This changed the approach to breast cancer for millions of women and has allowed the vast majority to preserve their breasts despite a cancer diagnosis. Recently, however, the pendulum has begun to swing back and an increasing number of women are choosing to undergo mastectomy or even bilateral mastectomy (removal of both breasts), for a variety of reasons. Two women in the public eye, actress Christina Applegate and E! News host Giuliana Rancic have publicly discussed their decision to undergo bilateral mastectomy.

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    Women with advanced ovarian cancer who had another brand of BRCA test and who are being considered for treatment with olaparib Lynparza after three or more previous. Therapeutic approaches include surgery, radiation therapy, and. For postmenopausal women, either tamoxifen or anastrozole are acceptable options. ○Bilateral mastectomy – For women who have undergone bilateral. Then your double mastectomy will remove your breast tissue, so should. Then after all that treatment the tamoxifen will help your body mop up.

    Occasionally a woman will present with lymph node metastases in the axilla or supraclavicular nodes which on biopsy shows adenocarcinoma, but nothing can be found in the breast, even on mammogram. The NCCN has guidelines for evaluating these patients. If the nodes are only in the axilla it is typical to treat the patient like stage II breast cancer. If the nodes are more advanced (including the supraclavicular nodes) it is common to start with chemotherapy and then proceed with surgery followed by radiation: MRI being positive in for breast cancer in 64- 100%. Series of 234 had mastectomy and cancer was found in 65%. Local Control with breast radiation alone = 73, 83, 75, 92, 100 and 100% and 5 year survival was 75-100%. Local breast relapse with no therapy in 78 cases was 44%. Dear Onco Link "Ask The Experts,"I had a mastectomy at age 36. The pathology report indicated the presence of both DCIS and LCIS. No lymph node involvement was seen and the estrogen receptor status was negative, so I had no further treatment. Recently, at age 49, I was diagnosed with invasive ductal cancer of my other remaining breast and had a second mastectomy. There was no lymph node involvement, but this cancer was estrogen receptor positive. My oncologist recommends I take Tamoxifen as I am premenopausal. I read that Tamoxifen helps prevent recurrent breast cancer, but how would this benefit me, since I have already had both breasts removed and no lymph node involvement?

    Tamoxifen after bilateral mastectomy

    SWOG-8814 Tamoxifen With or Without, Ductal carcinoma in situ Treatment and prognosis - UpToDate

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  3. Tamoxifen C26H29NO CID 2733526 - structure, chemical names, physical and chemical properties, classification, patents, literature, biological activities, safety.

    • Tamoxifen C26H29NO - PubChem.
    • Reason for Tamoxifen after bilateral MX? - Breast Cancer Care..
    • Preventive mastectomy - Wikipedia.

    I read that Tamoxifen helps prevent recurrent breast cancer, but how would this benefit me, since I have already had both breasts removed and. Lymph Node Metastases with No Obvious Cancer in the Breast Occult Primary or T0 Occasionally a woman will present with lymph node metastases in the axilla or. What are the risks and benefits of tamoxifen and other hormonal treatments. remove the cancer either lumpectomy/partial mastectomy or mastectomy. Tamoxifen therapy after surgery for early-stage breast cancer reduces.

     
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