Chloroquine has long been used in the treatment or prevention of malaria from Plasmodium vivax, P. malariae, excluding the malaria parasite Plasmodium falciparum, for it started to develop widespread resistance to it. Chloroquine has been extensively used in mass drug administrations, which may have contributed to the emergence and spread of resistance. Plaquenil how long does it take to work Plaquenil toxicity bull's eye maculopathy Hydroxychloroquine 100 mg tablet An alternative to chloroquine for prophylaxis only in areas with chloroquine-sensitive malaria 310 mg base 400 mg salt orally, once/week 5 mg/kg base 6.5 mg/ kg salt orally, once/week, up to maximum adult dose of 310 mg base Begin 1–2 weeks before travel to malarious areas. Malaria during pregnancy poses a serious threat to both mother and fetus. Chloroquine can be used during pregnancy in areas where Plasmodium species are susceptible, but there is no other safe and effective prophylactic regimen, so pregnant women should avoid travel to chloroquine-resistant areas whenever possible. Chloroquine CQ was the cornerstone of anti-malarial treatment in Africa for almost 50 years, but has been widely withdrawn due to the emergence and spread of resistance. Recent reports have suggested that CQ-susceptibility may return following the cessation of CQ usage. Here, we monitor CQ sensitivity and determine the prevalence of genetic polymorphisms in the CQ resistance transporter. In areas where resistance is present, other antimalarials, such as mefloquine or atovaquone, may be used instead. It is recommended to check if chloroquine is still effective in the region prior to using it. Chloroquine sensitive malaria areas CDC - Malaria - Malaria Worldwide - How Can Malaria Cases and., Malaria - Infectious Diseases - MSD Manual Professional Edition Drugs used in chloroquine resistant malaria Sep 15, 2001 A number of agents of diverse chemical structures and properties selectively enhance the activity of chloroquine against chloroquine-resistant but not chloroquine-sensitive malaria parasites in vitro 37, 67–70. Better understanding of the mechanism of resistance reversal and the role of PfCRT will help in evaluating these agents and perhaps in identifying new candidate compounds for drug development. Chloroquine-Resistant Malaria The Journal of Infectious.. Return of chloroquine sensitivity to Africa? Surveillance of.. Revised Recommendations for Preventing Malaria in Travelers.. Chloroquine is FDA-approved for the treatment and prophylaxis of uncomplicated malaria in countries where chloroquine-sensitive malaria certain strains of P. falciparum, P. ovale, P. vivax, and P. malariae is present. These countries include Mexico, areas of Central America to the west of the Panama Canal, the Caribbean, East Asia, as well as some Middle Eastern countries.1 The FDA also. Chloroquine is a medication used to prevent and to treat malaria in areas where malaria is known to be sensitive to its effects. Certain types of malaria, resistant strains, and complicated cases typically require different or additional medication. Chloroquine Phosphate. Chloroquine is used to prevent or treat malaria caused by mosquito bites in countries where malaria is common. Malaria parasites can enter the body through these mosquito bites, and then live in body tissues such as red blood cells or the liver.