Mutations in HLA genes seem to play a crucial role in the pathogenesis of some cases (but not all), likewise silica, aromatic and chlorinated solvents, ketones, trichloroethylene, welding fumes and white spirits exposure seems to contribute to the condition in a small proportion of affected persons. Vitamin D is implicated in the pathophysiology of the disease. Chloroquine phosphate 250 mg Plaquenil causing low wbc count What time of day to take plaquenil Immunosuppressants fall under a category of drugs referred to as DMARDs Disease-Modifying Anti-Rheumatic Drugs. ISN. Scleroderma Treatments and Clinical Trials ISN. Effect of disease-modifying anti-rheumatic drugs DMARDs on bone structure and strength in psoriatic arthritis PsA patients. Anti-malarial drugs, such as Plaquenil hydroxychloroquine, is often used to manage lupus and can also be effective in scleroderma. Plaquenil is thought to interfere with communication between immune cells, which can suppress the damaging effect of an overly active immune response without raising a patient’s risk of susceptibility to infections. Nonsterodial anti-inflammatory drugs and hydroxychloroquine Plaquenil help both conditions. Most patients with pure schleroderma do not benefit from corticosteroids. Methotrexate, azathioprine, prednisone or cyclophosphamide help lupus and overlap syndromes, and perhaps scleroderma lung disease. Typical scleroderma is classically defined as symmetrical skin thickening, with about 70% of cases also presenting with Raynaud's phenomenon, nail-fold capillary changes and antinuclear antibodies. An inverse correlation between plasma levels of vitamin D and scleroderma severity has been noted and vitamin D is known to play a crucial role in regulating (usually suppressing) the actions of the immune system. Plaquenil scleraderma Scleroderma and Systemic Sclerosis SSc An Overview., Lupus and Scleroderma - Scleroderma News Hydroxychloroquine and doxycyclineHow does hydroxychloroquine workChloroquine brand nameCan plaquenil cause restless leg syndrome Plaquenil is the brand name for the prescription drug hydroxychloroquine. It's used to treat and prevent malaria infection, and to reduce symptoms and progression of autoimmune diseases such as. Plaquenil Hydroxychloroquine - Side Effects, Dosage.. Lupus and Scleroderma Overview - Lupus International. Hydroxychloroquine Plaquenil. Localized scleroderma is a rare autoimmune disease with primary affection of the skin, and occasional involvement of the fat tissue, muscle, fascia, and bone. Depending on the clinical subtype, the spectrum of skin lesions ranges from singular plaque lesions to severe generalized or linear subtypes. which may lead to movement restrictions and permanent disability. See how 938 people just like you are living with scleroderma. Learn from their data and experience. Dismiss this notification PatientsLikeMe would like to remind you that your browser is out of date and many features of the website may not function as expected. Plaquenil Perceived effectiveness. Plaquenil hydroxychloroquine belongs to a group of medicines called quinolines. Plaquenil is used to treat or prevent malaria, a disease caused by parasites that enter the body through the bite of a mosquito. Malaria is common in areas such as Africa, South America, and Southern Asia.