Chloroquine macrophages

Discussion in 'Canada Pharmaceuticals Online' started by bugmaster, 03-Mar-2020.

  1. docker Well-Known Member

    Chloroquine macrophages


    Chloroquine has been extensively used in mass drug administrations, which may have contributed to the emergence and spread of resistance. It is recommended to check if chloroquine is still effective in the region prior to using it.

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    Chloroquine enters the red blood cell by simple diffusion, inhibiting the parasite cell and digestive vacuole. Chloroquine then becomes protonated to CQ2+, as the digestive vacuole is known to be acidic pH 4.7; chloroquine then cannot leave by diffusion. Hydroxychloroquine HCQ, sold under the brand name Plaquenil among others, is a medication used for the prevention and treatment of certain types of malaria. Specifically it is used for chloroquine-sensitive malaria. Other uses include treatment of rheumatoid arthritis, lupus, and porphyria cutanea tarda. It is taken by mouth. It is also being used as an experimental treatment for SARS-CoV-2. The macrophage is a central player in atherosclerotic progression. Insidious macrophage infiltration of the nascent plaque, phagocytosis of deposited lipid and cellular debris, foam cell formation.

    The Centers for Disease Control and Prevention recommend against treatment of malaria with chloroquine alone due to more effective combinations. In areas where resistance is present, other antimalarials, such as mefloquine or atovaquone, may be used instead.

    Chloroquine macrophages

    Effects of chloroquine on viral infections an old drug., Hydroxychloroquine - Wikipedia

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  7. Resetting tumor-associated macrophages TAMs is a promising strategy to ameliorate the immunosuppressive tumor microenvironment and improve innate and adaptive antitumor immunity. Here we show that chloroquine CQ, a proven anti-malarial drug, can function as an antitumor immune modulator that switches TAMs from M2 to tumor-killing M1 phenotype.

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    Feb 28, 2018 Resetting tumor-associated macrophages TAMs is a promising strategy to ameliorate the immunosuppressive tumor microenvironment and improve innate and adaptive antitumor immunity. Here we show that chloroquine CQ, a proven anti-malarial drug, can function as an antitumor immune modulator that switches TAMs from M2 to tumor-killing M1 phenotype. This study aimed to determine any alteration in the killing of Staphylococcus aureus in murine peritoneal macrophages when chloroquine CQ is used alone compared with when it is used in combination with ciprofloxacin CIP or azithromycin AZM. The. TY - JOUR. T1 - A chloroquine-induced macrophage-preconditioning strategy for improved nanodelivery. AU - Wolfram, Joy. AU - Nizzero, Sara. AU - Liu, Haoran

     
  8. Valeri4 Moderator

    Plaquenil is the brand name for the prescription drug hydroxychloroquine. Hydroxychloroquine Side Effects, Dosage, Uses, and More Rheumatoid Arthritis Treatment Options Johns Hopkins. Hydroxychloroquine Compared to Alternatives -
     
  9. ghopstop User

    Plaquenil, Plaquenil Sulfate, Quineprox hydroxychloroquine. Brand Names Plaquenil, Plaquenil Sulfate, Quineprox Generic Name hydroxychloroquine. What is hydroxychloroquine Plaquenil, Plaquenil Sulfate, Quineprox? What are the possible side effects of hydroxychloroquine Plaquenil, Plaquenil Sulfate, Quineprox?

    Brand name Plaquenil TM - healthdirect