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    Atret Cream 0.025% is used for maintenance treatment of acne vulgaris of the face, chest or back, including pimples (papules), whiteheads (pustules) and blackheads (comedones) and can also be used to treat acne cysts, which can be deep, painful and inflamed. Atret Cream 0.025% may also be used to help reduce visible signs of ageing on the face by fading age spots, reducing fine wrinkles and reducing the roughness of dry skin, caused by sun damage and aging, as it promotes skin turnover to replace old damaged skin with new skin. Atret Cream 0.025% contains tretinoin, which is an active metabolite of Vitamin A and is a keratolytic medication. Tretinoin in Atret Cream 0.025% works by binding to specific retinoic acid receptors in the nucleus of skin cells that affects the way skin cells behave and this regulates cell growth and differentiation. Tretinoin is thought to act by enhancing skin epithelial cell proliferation and accelerating epithelial differentiation; it also has anti-inflammatory properties. Acne is often associated with puberty when a surge of androgen hormones can over stimulate the sebaceous glands (oil producing glands in hair follicles). Skin cells that are shed from the lining of the hair follicle become trapped in sebum forming a plug below the surface of the skin, clogging the pores, which then attracts bacteria, so that the clogged pores become infected and inflamed, causing an acne outbreak. It may decrease the number and severity of acne pimples and promote quick healing of pimples that do develop. Tretinoin belongs to a class of medications called retinoids. Read the Patient Information Leaflet if one is available from your pharmacist. Consult your doctor or pharmacist if you have questions. Gently clean the affected skin with a mild or soapless cleanser and pat dry. Use your fingertips to apply a small amount of medication (about the size of a pea) in a thin layer, usually once daily at bedtime or as directed by your doctor. A gauze pad or cotton swab can be used to apply the liquid. For some preparations, you should wait 20-30 minutes after cleaning your face before applying this medication. Consult the label directions, the Patient Information Leaflet, or your pharmacist if you have any questions. Do not apply to the inner lip area or inside the nose/mouth.

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