My peripheral neuropathy actually went away too, and my rheumy thinks it was a rare, toxic side-effect of the Plaquenil. Get emergency medical help if you have any of these signs of an allergic reaction while taking hydroxychloroquine: hives; difficulty breathing; swelling of your face, lips, tongue, or throat. Fatigue is part of malaria, which is the normal use of this medication. Chloroquine and jnk inhibitor clinical trial If hydroxychloroquine was ineffective would it be effective with methotrexate Plaquenil side effects. Get emergency medical help if you have signs of an allergic reaction to Plaquenil hives; difficulty breathing; swelling of your face, lips, tongue, or throat. Taking Plaquenil long-term or at high doses may cause irreversible damage to the retina of your eye. Hydroxychloroquine offers potential efficacy for CU and is relatively benign compared with most other therapeutic approaches. OBJECTIVE The aim of the chronic autoimmune urticaria study and evaluation was to evaluate the efficacy of hydroxychloroquine in patients with chronic idiopathic urticaria. Jun 17, 2015 An autoimmune disease. According to the American Osteopathic College of Dermatology, about half the cases of chronic idiopathic hives are due to immune systems that attack the body's own tissues. This is not a complete list of side effects and others may occur. Call your doctor at once if you have a serious side effect such as:muscle weakness, twitching, or uncontrolled movement;loss of balance or coordination;blurred vision, light sensitivity, seeing halos around lights;pale skin, easy bruising or bleeding;confusion, unusual thoughts or behavior; orseizure (convulsions). Less serious side effects of hydroxychloroquine may include:headache, ringing in your ears, spinning sensation;nausea, vomiting, stomach pain;loss of appetite, weight loss;mood changes, feeling nervous or irritable;skin rash or itching; or hair loss. Will plaquenil help autoimmune urticaria Plaquenil for fatigue and pain DailyStrength, Impact of hydroxychloroquine therapy on chronic urticaria. What type of medication is plaquenil Answering this question should help allergists treat chronic urticaria with a more evidence based approach. To date there has one been one prospective trial evaluating hydroxychloroquine in hives, and although it showed a trend towards efficacy 0.05p0.10, it was not statistically significant. Hydroxychloroquine Efficacy in Chronic Urticaria - Full.. Surprising Triggers of Chronic Hives Everyday Health. What Conditions does Plaquenil Treat? - WebMD. A 1-year follow-up study has shown efficacy of CsA in treatment of autoimmune urticaria, even in low doses 1.5-2.5 mg/kg/day given over 5 months. The main side effects occurring with CsA are renal damage which may be reversible on stopping medications and hypertension. A 55 year-old female with solar urticaria. Seen originally on 12/16 at rheum/derm for muscle weakness and rash with mild increase CPK and atelase, ANA 1-40 and normal CBD. Antihistone and typical SLE w/u negative. Plaquenil no help. Tests then showed +++ in visible spectrum and less in UVA spectrum. - UVB and porphyrins. Plaquenil is a DMARD which has been prescribed for years to treat rheumatoid arthritis, lupus, juvenile rheumatoid arthritis, and other autoimmune diseases. When the first biologic DMARD received FDA-approval in 1998, and as other biologics followed in subsequent years, it appeared as though Plaquenil would become less prescribed.